Calicut is fairly well connected to major Indian cities by road, rail and air.

Air

Calicut has an international airport and has daily direct flights from Chennai and Mumbai and thrice weekly flights from Bangalore. Popular carriers include Jet Airways, Indian Airlines and Kingfisher.
Calicut is also well connected to the UAE and has direct flights from Dubai and Sharjah.
Book flight tickets.

Rail

Calicut is also well connected by rail from cities like Chennai, Bangalore and Thiruvananthapuram. Daily trains like Mangalore Mail and Mangalore Express leave Chennai late evening and arrive in Calicut the following morning. Calicut is also connected to Delhi by rail.
Make railway reservations.

Road

Calicut is well connected to cities like Mangalore, Kochi, Thiruvananthapuram, Chennai, Bangalore and Coimbatore by road. It is actually a pleasure to drive from Bangalore to Calicut through Gundulpet and Sulthan Battery. But be cautioned that the small stretch of jungle you have to pass through may have wild elephants and moving in late hours along in small vehicles is not advised.